Pet Studies on Amino Acid Metabolism and Protein Synthesis

Preface. Part 1: Biochemistry and Animal Studies. 1. Cerebral protein turnover: aspects and problems; A. Lajtha, D. Dunlop, M. Banay-Schwartz. 2. Determination of regional rates of cerebral protein synthesis in vivo with L-[1-14C]leucine as the tracer amino acid; C. Beebe Smith. 3. Methionine metabolism in rat brain; P. Bobillier, E. Grange, A. Gharib, M. Leclerc, N. Sarda, P. Lepetit. 4. Protein synthesis studies in rats with methionine; A.M. Planas, C. Prenant, B.M. Mazoyer, S. Chadan, D. Comar, L. DiGiamberardino. Part 2: PET Radiochemistry. 5. Carbon-11 amino acids, labelling and metabolites; W. Vaalburg, P.H. Elsinga, A.M.J. Paans. 6. Quality control aspects in the preparation of [11C]-methionine; K. Nögren. 7. Production of L-[18F]fluoro amino acids for protein synthesis: overview and recent developments in nucleophilic syntheses; C. Lemaire. 8. Biochemistry and evaluation of fluoroamino acids; H.H. Coenen. Part 3: Amino Acid Uptake Modelling. 9. Kinetic modelling of fluorotyrosine uptake; K. Wienhard, K. Herholz, H.H. Coenen, J. Rudolf, P. Kling, G. Stöcklin, W.-D. Heiss. 10. Kinetic modelling of carbon-11 labelled amino acids; G. Blomqvist. 11. Carbon-11 labelled tyrosine as a probe for modelling the protein synthesis rate; A.M.J. Paans, P.H. Elsinga, W. Vaalburg. 12. Kinetic modelling of carbon-11 labelled methionine; H. Lundqvist. 13. Apporaches to quantitative analysis of amino acid transport and metabolism; G.-J. Meyer, J. van den Hoff, W. Burchert, H. Hundeshagen.14. 11C-methionine and 82rubidium uptake in human brain tumors: comparison of carrier dependent blood-brain barrier transport; Y. Roelcke, E.W. Radü, K.L. Leenders. Part 4: Clinical Applications. 15. Tracers for clinical evaluation of gliomas: a neurologist's view; K. Herholz. 16. PET studies of amino acid metabolism: integration in clinical routine and current research on intracranial tumours; K. Ericson. 17. Uptake of [11C]methionine in non-brain tumors; S. Leskinen-Kallio. 18. Utilization of amino acid transport rates for the differential diagnosis of brain tumors; G.-J. Meyer, W. Burchert, K.-F. Gratz, H. Hundeshagen. 19. Use of amino acid uptake and protein synthesis rates for tumour diagnosis; H. Lundqvist. 20. 11C-methionine uptake in brain tumors measured by PET: early clinical results; B. Sadzot, B. Kaschten, G. Delfiore, J.M. Peters, A. Stevenaert, G. Franck, D. Comar. 21. 11C-labelled methionine uptake in gliomas: modification after therapy and metbolic correlations; M.-C. Petit-Taboué, F. Dauphin, J.-M. Derlon. 22. In vivo incorporation of labelled methionine into proteins in brain tumors; A.M. Planas, B. Kaschten, B. Sadzot, A. Stevenaert, L. DiGiamberardino, D. Comar.